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butabarbital will reduce the level or outcome of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Outcome of coadministering a strong CYP3A4 inducer with fedratinib hasn't been researched.butabarbital will minimize the extent or influence of pioglitazone by impacting hepatic/intestinal enzyme CYP3A